nateglinide

Generic Name: nateglinide
Other Brand Names: Starlix
Overview Uses Side Effects Precautions Interactions Overdose

What is nateglinide (oral)?

Nateglinide is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas.

Nateglinide is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with nateglinide if needed.

Nateglinide may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking nateglinide (oral)?

Do not use this medication if you are allergic to nateglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking nateglinide, tell your doctor if you are allergic to any medications, or if you have liver disease or gout. You may not be able to use nateglinide, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether nateglinide passes into breast milk or if it could be harmful to a nursing baby. Do not take nateglinide without telling your doctor if you are breast-feeding a baby.

How should I take nateglinide (oral)?

Take nateglinide exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription.

Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency. Do not change your dose of nateglinide without first talking to your doctor.

Take this medicine with a full glass of water.

Nateglinide is usually taken 3 times daily, within 30 minutes before eating a meal. Follow your doctor’s instructions. If you skip a meal, do not take your dose of nateglinide. Wait until your next meal.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

To be sure this medication is helping your condition, you will need to check your blood sugar at home. Your blood will also need to be tested by your doctor on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Nateglinide is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

It is important to take nateglinide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store nateglinide at room temperature away from moisture and heat.

What happens if I miss a dose of nateglinide (oral)?

Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. If it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

Where can I get more information about nateglinide (oral)?
Your pharmacist has information about nateglinide (oral) written for health professionals that you may read.
What are the possible side effects of nateglinide (oral)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • seizure (convulsions); or

  • jaundice (yellowing of the skin or eyes).

Other less serious side effects are more likely to occur, such as:

  • runny or stuffy nose, sneezing, cough, cold or flu symptoms;

  • diarrhea, nausea;

  • back pain;

  • dizziness; or

  • joint pain or stiffness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about nateglinide (oral)?

Do not use this medication if you are allergic to nateglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia.

Nateglinide is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

It is important to take nateglinide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What should I avoid while taking nateglinide (oral)?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Do not use nateglinide if you are in a state of diabetic ketoacidosis. Call your doctor for treatment.

What other drugs will affect nateglinide (oral)?

You may be more likely to have hyperglycemia (high blood sugar) if you are taking nateglinide with other drugs that raise blood sugar. Drugs that can raise blood sugar include:

  • isoniazid;

  • diuretics (water pills);

  • steroids (prednisone and others);

  • phenothiazines (Compazine and others);

  • thyroid medicine (Synthroid and others);

  • birth control pills and other hormones;

  • seizure medicines (Dilantin and others); and

  • diet pills or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking nateglinide with other drugs that lower blood sugar. Drugs that can lower blood sugar include:

  • nonsteroidal anti-inflammatory drugs (NSAIDs);

  • aspirin or other salicylates (including Pepto-Bismol);

  • sulfa drugs (Bactrim and others);

  • a monoamine oxidase inhibitor (MAOI);

  • beta-blockers (Tenormin and others); or

  • probenecid (Benemid).

There may be other drugs not listed that can affect nateglinide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What happens if I have an overdose of nateglinide (oral)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a nateglinide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, loss of consciousness, and coma.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Content provided by Multum - Last Updated 2/11/2008